Original scientific paper
Nonrandomized comparison of radical prostatectomy versus external radiation in patients with prostate cancer: a 14-year follow-up in Karlovac General Hospital
Davorin Katušin
; Department of Urology, Karlovac General Hospital, Karlovac, Croatia
Slavica Klarić-Vučinić
; Department of Urology, Karlovac General Hospital, Karlovac, Croatia
Miljanko Križ
; Department of Urology, Karlovac General Hospital, Karlovac, Croatia
Željko Poka
; Department of Urology, Karlovac General Hospital, Karlovac, Croatia
Jasminka Sušanj
; Department of Urology, Karlovac General Hospital, Karlovac, Croatia
Doroteja Lipšinić
; Department of Urology, Karlovac General Hospital, Karlovac, Croatia
Abstract
Radical prostatectomy (RP) and radical external radiotherapy (RT) are standard curative options for patients with localized prostate cancer (CaP). There are no conclusive randomized studies comparing these two methods in terms of oncological outcome. The aim of our nonrandomized study was to compare oncological outcome of our patients with localized CaP treated surgically with those underwent RT.
We analyzed 115 consecutive patients with newly diagnosed localized CaP in Karlovac General Hospital from January 1994 to January 2008. Sixty four (55.7%) underwent RP and 51 (44.3%) external RT. The patients in RP group were significantly younger and with lower serum prostate-specific antigen (PSA) value, while there was no significant difference between the patients in RP and RT group in term of pathologic stage, pathologic grade (Gleason score) and risk group distribution. The median follow-up was 44 months (range 5-168). There was no difference in PSA recurrence rate between the patients in RP and RT group. Time to PSA recurrence was significantly shorter after RP (median 16 months, range 2-86) than after RT (median 36, range 10-73). The overall 5-year PSA recurrence-free survival rate, estimated by Kaplan-Meier method was 57.2%. There was no difference in PSA recurrence-free survival between the patients in RP and RT group.
Although nonrandomized and with a limited follow-up, our study supports a general consensus that there is no significant difference in oncological outcome between the patients with localized CaP treated with RP and those submitted to RT.
Keywords
prostate cancer; radiotherapy; radical prostatectomy; survival
Hrčak ID:
280629
URI
Publication date:
22.11.2007.
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