Short communication, Note

https://doi.org/10.2478/acph-2023-0011

Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report

SIMONA SOVOVÁ ; Department of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy, 041 81 Košice, Slovak Republic; Institute of Chemistry, Faculty of Science, P. J. Šafárik University, 041 54 Košice, Slovak Republic
ŠTEFÁNIA LACA MEGYESI ; Department of Pharmaceutical Technology, Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy, 041 81 Košice, Slovak Republic
DAGMAR MUDROŇOVÁ ; Department of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, 041 81 Košice, Slovak Republic
PAVOL MUDROŇ ; Clinic of Ruminants of the University of Veterinary Medicine and Pharmacy, 041 81 Košice, Slovak Republic
JARMILA HARVANOVÁ ; Department of Chemistry, Biochemistry and Biophysics, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, Slovak Republic
MICHAELA RENDOŠOVÁ orcid.org/0000-0002-1097-2327 ; Institute of Chemistry, Faculty of Science, P. J. Šafárik University, 041 54 Košice, Slovak Republic
MICHAL GOGA ; Department of Botany, Institute of Biology and Ecology, Faculty of Science, P. J. Šafárik University, 040 01 Košice, Slovak Republic
ĽUDMILA TKÁČIKOVÁ ; Department of Chemistry, Biochemistry and Biophysics, University of Veterinary Medicine and Pharmacy, 041 81 Košice, Slovak Republic
ZUZANA VARGOVÁ orcid.org/0000-0001-8846-6697 ; Institute of Chemistry, Faculty of Science, P. J. Šafárik University, 041 54 Košice, Slovak Republic

Abstract

The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)2]NO3·H2O (AgNam), [Ag2(HGly)2]n(NO3)2n (AgGly) (Nam– nicotinamide, Gly – glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in in vivo case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential. Moreover, the creams loaded with AgGly and AgNam showed higher antibacterial effects against S. aureus and B. subtilis than the cream loaded with AgSD. In terms of appearance, all cream samples were opaque and odourless, and no phase separation was observed. Creams were soluble in water (o/w emulsions) and they had a pseudoplastic behaviour. The pH of the creams was in the range of 4.87–5.75. No visible changes were observed in the case of commercially used AgSD cream during one month testing period at conditions –16 ± 1 °C; 6 ± 1 °C and 56 % relative humidity; 20 ± 1 °C and 58 % relative humidity and 40 ± 1 °C and 75 % relative humidity. However, creams containing AgGly and AgNam changed their colour depending on the tested conditions.

Keywords

silver(I) antimicrobial complexes; creams; evaluation; antibacterial activity; pilot in vivo case report

Hrčak ID:

284922

URI

https://hrcak.srce.hr/284922

Publication date:

30.6.2023.

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