Original scientific paper
https://doi.org/10.20471/LO.2022.50.02-03.13
Complete pathological response following neoadjuvant chemoradiotherapy in locally advanced colorectal carcinoma
Ozana Miličević
; School of Medicine, University of Zagreb, Zagreb, Croatia
Ines Trkulja
; School of Medicine, University of Zagreb, Zagreb, Croatia
Andrija Matijević
; School of Medicine, University of Zagreb, Zagreb, Croatia
Loris Ćurt
; Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Patricija Sesar
; Department of Oncological Pathology and Clinical Cytology, Ljudevit Jurak University Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Meliha Solak
; Division of Oncology and Radiotherapy, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Snježana Ramić
; Department of Oncological Pathology and Clinical Cytology, Ljudevit Jurak University Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Iva Kirac
; Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Abstract
Background: The prognosis of rectal cancer has improved with neoadjuvant treatment for locally advanced disease. Twenty percent of patients respond to treatment with complete pathological regression, which is clinically estimated with magnetic resonance imaging.
Aim: describe the properties of the pathological complete response group of patients at our institution
Materials and methods: All selected patients received LCCRT at the University Hospital for Tumors Sestre milosrdnice University Hospital Center, Zagreb, between January 2014 and December 2019 and were later surgically treated at the same facility.
Results: We identified 23 patients with complete pathological responses, of which, despite surgery, seven progressed. We recorded a higher proportion of female patients in that group and younger age of onset. MRI preoperatively was not yet predictive of a complete pathological response.
Conclusion: The proportion of patients with a complete pathological response is 16% in this cohort. All patients underwent surgery but did not receive consolidating therapy. About 30% progressed during the observed period.
Keywords
neoadjuvant therapy; rectal cancer; complete pathological response
Hrčak ID:
288515
URI
Publication date:
22.12.2022.
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