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Croatica Chemica Acta, Vol. 96 No. 1, 2023.

Original scientific paper

https://doi.org/10.5562/cca4007

Analysis of Antitumor Potential of Xanthene Compounds in Lymphoma Cells

Esma Bilajac orcid id orcid.org/0000-0001-5702-7990 ; Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Hrasnička cesta 15, 71000 Sarajevo, Bosnia and Herzegovina
Una Glamočlija orcid id orcid.org/0000-0003-1206-6990 ; University of Sarajevo - Faculty of Pharmacy, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Amar Osmanović orcid id orcid.org/0000-0002-4206-6177 ; University of Sarajevo - Faculty of Pharmacy, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Lejla Mahmutović orcid id orcid.org/0000-0002-7358-5009 ; Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Hrasnička cesta 15, 71000 Sarajevo, Bosnia and Herzegovina
Abas Sezer orcid id orcid.org/0000-0002-8716-1768 ; Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Hrasnička cesta 15, 71000 Sarajevo, Bosnia and Herzegovina
Sunčica Roca orcid id orcid.org/0000-0001-9562-6820 ; NMR Centre, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia
Selma Špirtović-Halilović ; University of Sarajevo - Faculty of Pharmacy, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Mirsada Salihović orcid id orcid.org/0000-0001-7497-4084 ; University of Sarajevo - Faculty of Pharmacy, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
Altijana Hromić-Jahjefendić orcid id orcid.org/0000-0001-7222-8678 ; Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Hrasnička cesta 15, 71000 Sarajevo, Bosnia and Herzegovina
Elma Veljović orcid id orcid.org/0000-0003-1129-1491 ; University of Sarajevo - Faculty of Pharmacy, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina

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Abstract

Antitumor activity of two newly and sixteen previously synthesized 9-arylsubstituted 2,6,7-trihydroxyxanthene-3-ones on diffuse large B-cell lymphoma cells were analyzed in this study. Xanthene derivatives are characterized with numerous therapeutic applications, including anticancer, antioxidant, anti-inflammatory and other activities. In silico molecular docking analysis suggests significant binding affinities of certain compounds toward Akt and NF-κB proteins as two major players of cell proliferation and differentiation. Results of WST-8 assay indicate mild or no activity of xanthene compounds on cell viability of HBL-1 and DHL-4 cell lines belonging to ABC and GCB DLBCL subtypes, respectively. Western blotting showed stimulatory activity of certain compounds, with increased expression of Akt in HBL-1 and DHL-4 cells. Our results provide an insight into activation of compensatory Akt mechanism in DLBCL models that could be an important step for further approaches in application of dual inhibitors for cancer treatment to achieve greater therapeutic effectiveness and drug resistance escape.

Keywords

xanthene-3-ones; cancer; diffuse large B-cell lymphoma; compensatory mechanisms; molecular docking analysis

Hrčak ID:

307474

URI

https://hrcak.srce.hr/307474

Publication date:

6.7.2023.

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