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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 77 No. 1, 2023.

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CLINICAL AND PATHOLOGICAL PRESENTATIONS OF PATIENTS WITH HPV POSITIVE OROPHARYNGEAL CARCINOMA – A SOUTH CROATIAN STUDY

LUKA MINARIK orcid id orcid.org/0000-0002-4867-3648 ; Institute of Emergency Medicine of Zagreb County, Zagreb, Croatia; Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, Split, Croatia *
BRACO BOŠKOVIĆ ; Department of Otorhinolaryngology, Head and Neck Surgery, Split University Hospital Center, Split, Croatia
ANA DUNATOV ; Department of Pathology, Forensic Medicine and Cytology, Split University Hospital Center, Split, Croatia
JELENA VICULIN ; Department of Oncology and Radiotherapy, Split University Hospital Center, Split, Croatia
BENJAMIN BENZON ; Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, Split, Croatia
MERICA GLAVINA DURDOV ; Department of Pathology, Forensic Medicine and Cytology, Split University Hospital Center, Split, Croatia

* Corresponding author.

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Abstract

Objective: The objective of this study was to analyze the influence of human papilloma virus (HPV) in patients with oropharyngeal
squamous cell carcinoma (OPSCC) from southern Croatia on survival, clinical outcomes, and pathological features. Methods: We
analyzed HPV DNA presence and p16 immunohistochemistry staining in 68 formalin-fixed paraffin-embedded samples from patients diagnosed with OPSCC at the Split University Hospital Center between 2013 and 2017. Histologic features were analyzed
using a light microscope. Clinical data were retrospectively collected from patient records and analyzed for HPV status. Results:
In this study, 10.29% of patients were HPV positive (HPV+). Lymphocyte invasion was more prominent in p16 positive OPSCC.
Overall survival (OS) was better in HPV+ and p16+ patients. HPV status is a significant prognostic variable for patients from south
Croatia with OPSCC. Conclusion: HPV seems to have a minor influence on OPSCC in south Croatia in comparison to other Western European countries and the USA. Although the influence of HPV on survival was significant, traditional risk factors were more important in the carcinogenesis of OPSCC in our population.

Keywords

Croatia; head and neck neoplasms; histology; human papilloma virus 16; oropharyngeal neoplasms; squamous cell carcinoma

Hrčak ID:

310005

URI

https://hrcak.srce.hr/310005

Publication date:

22.11.2023.

Article data in other languages: croatian

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