Original scientific paper
https://doi.org/10.31306/s.66.2.1
Strategy to evaluate the impact of formaldehyde in anatomical pathology laboratory part III: Equivalence test procedure for air monitoring methods
Stefano Dugheri
; Careggi University Hospital, Industrial Hygiene and Toxicology Laboratory, Florence, Italy
*
Giovanni Cappelli
; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Lucia Isolani
; Occupational Health Safety Unit, Regional Health Unit, Macerata, Italy
Lucia Trevisani
; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Donato Squillaci
; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Elisabetta Bucaletti
; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Jacopo Ceccarelli
; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Simone Pettinari
; Occupational Helath Safety Unit, Regional Health Unit, Macerata, Italy
Giovanni Amagliani
; Occupational Helath Safety Unit, Regional Health Unit, Macerata, Italy
Niccolò Fanfani
; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Nicola Mucci
; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Giulio Arcangeli
; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
* Corresponding author.
Abstract
To date, formaldehyde (FA) is one of the more common chemicals and its use is widespread around the world in different sectors, especially in chemical facilities and health care. FA is widely used in working activities owing to its chemical and physical properties. However, it also represents a concerning hazard for the workers’ health due to its toxicity and recognized carcinogenicity. The FA exposure evaluation in occupational setting has arisen interest in the scientific community that leads to the development of several analytical instruments in order to assess both long term and short-term exposure.
The paper presents and discusses an equivalence tests procedure via the 2.4-dinitrophenylhydrazine (DNPH)-active air sampling formaldehyde (FA) reference method and two non-reference instruments based on continuous, direct reading monitoring, namely ProCeas® (AP2E) and NEMo XT (Ethera). The FA standard atmosphere calibration system was used to check the reference method by Pearson’s test. Subsequently, the Passing-Bablok test was carried out between the non-reference methods and the DNPH method for potential systematic or proportional errors, and finally the Bland-Altman plot was applied to determine the mean bias and the variances of the recorded values by the reference and non-reference methods in on-field sampling. The results showed a good correlation between the non-references method and the DNPH ones, suggesting their possible applications in heterogeneous occupational scenarios.
Keywords
formaldehyde, equivalence procedure, occupational monitoring
Hrčak ID:
318929
URI
Publication date:
8.7.2024.
Visits: 0 *