Original scientific paper

Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo

Marina Pavlak orcid.org/0000-0003-0618-0199 ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Marko Radačić ; Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Jure Jerčić ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ranko Stojković ; Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Ksenija Vlahović ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Biserka Žinić ; Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia

Abstract

The aim of the present study was to investigate in vivo toxic effects and to find acute toxic doses (LD50) of novel N-sulfonyl derivatives of pyrimidine nucleobases uracil and cytosine. Six N-1-sulfonyluracil derivatives (1, 2, 6, 7, 8, and 9) and two N-1-sulfonylcytosine (4, 12) and N-1,NH-4-disulfonylcytosine (13) were evaluated in this study. All experiments were performed on 10-14- week-old male and female c57bl/6 zgr mice weighing 22-25 g at the time of treatment. The obtained data showed that derivatives 1, 2, 7, 12 and 13 cause less toxicity than derivatives 4, 6, 8 and 9. Compounds 2, 7, 12 and 13 did not cause death in mice in doses of 3000 mg/kg. Uracil derivative 8 has shown the highest toxicity, its acute toxic dose being 150 mg/kg, similar to the acute toxic dose of 5-fluorouracil.

Keywords

uracil; cytosine; N-sulfonylpyrimidine derivatives; mice

Hrčak ID:

31907

URI

https://hrcak.srce.hr/31907

Publication date:

19.8.2005.

Article data in other languages: croatian

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