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Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo

Marina Pavlak orcid id orcid.org/0000-0003-0618-0199 ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Marko Radačić ; Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Jure Jerčić ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ranko Stojković ; Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Ksenija Vlahović ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Biserka Žinić ; Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia


Puni tekst: engleski pdf 239 Kb

str. 311-316

preuzimanja: 684

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Sažetak

The aim of the present study was to investigate in vivo toxic effects and to find acute toxic doses (LD50) of novel N-sulfonyl derivatives of pyrimidine nucleobases uracil and cytosine. Six N-1-sulfonyluracil derivatives (1, 2, 6, 7, 8, and 9) and two N-1-sulfonylcytosine (4, 12) and N-1,NH-4-disulfonylcytosine (13) were evaluated in this study. All experiments were performed on 10-14- week-old male and female c57bl/6 zgr mice weighing 22-25 g at the time of treatment. The obtained data showed that derivatives 1, 2, 7, 12 and 13 cause less toxicity than derivatives 4, 6, 8 and 9. Compounds 2, 7, 12 and 13 did not cause death in mice in doses of 3000 mg/kg. Uracil derivative 8 has shown the highest toxicity, its acute toxic dose being 150 mg/kg, similar to the acute toxic dose of 5-fluorouracil.

Ključne riječi

uracil; cytosine; N-sulfonylpyrimidine derivatives; mice

Hrčak ID:

31907

URI

https://hrcak.srce.hr/31907

Datum izdavanja:

19.8.2005.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.483 *