Veterinarski arhiv, Vol. 75 No. 4, 2005.
Izvorni znanstveni članak
Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo
Marina Pavlak
orcid.org/0000-0003-0618-0199
; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Marko Radačić
; Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Jure Jerčić
; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ranko Stojković
; Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Ksenija Vlahović
; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Biserka Žinić
; Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia
Sažetak
The aim of the present study was to investigate in vivo toxic effects and to find acute toxic doses (LD50) of novel N-sulfonyl derivatives of pyrimidine nucleobases uracil and cytosine. Six N-1-sulfonyluracil derivatives (1, 2, 6, 7, 8, and 9) and two N-1-sulfonylcytosine (4, 12) and N-1,NH-4-disulfonylcytosine (13) were evaluated in this study. All experiments were performed on 10-14- week-old male and female c57bl/6 zgr mice weighing 22-25 g at the time of treatment. The obtained data showed that derivatives 1, 2, 7, 12 and 13 cause less toxicity than derivatives 4, 6, 8 and 9. Compounds 2, 7, 12 and 13 did not cause death in mice in doses of 3000 mg/kg. Uracil derivative 8 has shown the highest toxicity, its acute toxic dose being 150 mg/kg, similar to the acute toxic dose of 5-fluorouracil.
Ključne riječi
uracil; cytosine; N-sulfonylpyrimidine derivatives; mice
Hrčak ID:
31907
URI
Datum izdavanja:
19.8.2005.
Posjeta: 2.099 *