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Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo

Marina Pavlak ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Marko Radačić ; Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Jure Jerčić ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ranko Stojković ; Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Ksenija Vlahović ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Biserka Žinić ; Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia

Puni tekst: engleski, pdf (239 KB) str. 311-316 preuzimanja: 368* citiraj
APA 6th Edition
Pavlak, M., Radačić, M., Jerčić, J., Stojković, R., Vlahović, K. i Žinić, B. (2005). Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo. Veterinarski arhiv, 75 (4), 311-316. Preuzeto s https://hrcak.srce.hr/31907
MLA 8th Edition
Pavlak, Marina, et al. "Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo." Veterinarski arhiv, vol. 75, br. 4, 2005, str. 311-316. https://hrcak.srce.hr/31907. Citirano 22.11.2019.
Chicago 17th Edition
Pavlak, Marina, Marko Radačić, Jure Jerčić, Ranko Stojković, Ksenija Vlahović i Biserka Žinić. "Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo." Veterinarski arhiv 75, br. 4 (2005): 311-316. https://hrcak.srce.hr/31907
Harvard
Pavlak, M., et al. (2005). 'Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo', Veterinarski arhiv, 75(4), str. 311-316. Preuzeto s: https://hrcak.srce.hr/31907 (Datum pristupa: 22.11.2019.)
Vancouver
Pavlak M, Radačić M, Jerčić J, Stojković R, Vlahović K, Žinić B. Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo. Veterinarski arhiv [Internet]. 2005 [pristupljeno 22.11.2019.];75(4):311-316. Dostupno na: https://hrcak.srce.hr/31907
IEEE
M. Pavlak, M. Radačić, J. Jerčić, R. Stojković, K. Vlahović i B. Žinić, "Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo", Veterinarski arhiv, vol.75, br. 4, str. 311-316, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/31907. [Citirano: 22.11.2019.]

Sažetak
The aim of the present study was to investigate in vivo toxic effects and to find acute toxic doses (LD50) of novel N-sulfonyl derivatives of pyrimidine nucleobases uracil and cytosine. Six N-1-sulfonyluracil derivatives (1, 2, 6, 7, 8, and 9) and two N-1-sulfonylcytosine (4, 12) and N-1,NH-4-disulfonylcytosine (13) were evaluated in this study. All experiments were performed on 10-14- week-old male and female c57bl/6 zgr mice weighing 22-25 g at the time of treatment. The obtained data showed that derivatives 1, 2, 7, 12 and 13 cause less toxicity than derivatives 4, 6, 8 and 9. Compounds 2, 7, 12 and 13 did not cause death in mice in doses of 3000 mg/kg. Uracil derivative 8 has shown the highest toxicity, its acute toxic dose being 150 mg/kg, similar to the acute toxic dose of 5-fluorouracil.

Ključne riječi
uracil; cytosine; N-sulfonylpyrimidine derivatives; mice

Hrčak ID: 31907

URI
https://hrcak.srce.hr/31907

[hrvatski]

Posjeta: 633 *