Original scientific paper
https://doi.org/10.51558/2232-7568.2024.17.2. 43
Anticancer potential of pink pepper fruit essential oil: study on human cell lines of lung carcinoma (H460), cervical adenocarcinoma (HeLa) and colorectal carcinoma (HCT116)
Emir Horozić
; Faculty of Technology, University of Tuzla
*
Lamija Kolarević
orcid.org/0009-0002-7409-4735
Suada Cipurković
Merima Ibišević
Lejla Mekić
orcid.org/0000-0003-0242-3093
Melisa Šehić
orcid.org/0000-0003-0242-3093
Ermina Cilović Kozarević
orcid.org/0000-0003-0242-3093
Darja Husejnagić
Edina Huseinović
Maja Pođanin
orcid.org/0000-0003-0242-3093
Enida Karić
Mirela Radin
orcid.org/0000-0003-0242-3093
* Corresponding author.
Abstract
Schinus terebinthifolius Raddi is a plant species belonging to Anacardiaceae family, native to South America, with particular abundance in Brazil, Argentina and Paraguay. It is commonly known as Brazilian pepper tree. All plant parts have been used in traditional medicine for the treatment of several pathologies. In this paper, the cytotoxic effects of the essential oil of the commercial pink pepper fruit from the Tuzla market were investigated. To assess the cytotoxic potential, a tetrazolium salt reduction (MTT) viability assay was performed. The experiments were carried out on 3 human cell lines: lung carcinoma (H460), cervical adenocarcinoma (HeLa) and colorectal carcinoma (HCT116). Using GC/MS, 24 components of red pepper essential oil were identified, of which α-pinene, α-phellandrene, δ-3-carene and D-limonene dominate. The essential oil of the pink pepper fruit showed cytotoxic activity in the case of all tested cell lines under in vitro conditions.
Keywords
GC/MS analysis; cytotoxic activity; H460; HeLa; HCT116
Hrčak ID:
335772
URI
Publication date:
2.5.2025.
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