Original scientific paper
https://doi.org/10.20471/acc.2024.63.03-04.33
The Effect of Anesthesia on Postoperative Cognitive Dysfunction
Miro Bilić
; Department of Surgery, Zagreb University Hospital Center, Zagreb, Croatia
Martina Lukšić
; Community Health Center of Split-Dalmatia County, Split, Croatia
Martina Miklić Bublić
; Department of Anesthesiology, Resuscitation and Intensive Care Medicine and Pain Therapy, Zagreb University Hospital Center Zagreb, Zagreb, Croatia
Zrinka Orešković
; Department of Anesthesiology, Resuscitation and Intensive Care Medicine and Pain Therapy, Zagreb University Hospital Center Zagreb, Zagreb, Croatia
Davor Mijatović
; Department of Anesthesiology, Resuscitation and Intensive Care Medicine and Pain Therapy, Zagreb University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Vilena Vrbanović Mijatović
orcid.org/0000-0001-8568-1359
; Department of Anesthesiology, Resuscitation and Intensive Care Medicine and Pain Therapy, Zagreb University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
*
* Corresponding author.
Abstract
Postoperative cognitive dysfunction (POCD) is a newly developed cognitive function
deficit after surgery. The aim of the study was to determine the incidence of POCD after anesthesia and
possible risk factors. A prospective study was conducted on 90 patients scheduled for elective surgery under
general (60 patients) or regional (30 patients) anesthesia. Each patient completed the Montreal cognitive
assessment (MoCa) test the day before and the day after surgery. Data on comorbidities, previous
COVID-19 infection, demographic and anesthesia related data were also collected. The day after surgery,
POCD defined according to the 2 scores rule was present in 38 (42.2%) patients. A lower level of education
(p=0.023), previous COVID-19 infection (p=0.032), higher Charlson comorbidity index (CCI)
(p=0.014), and general anesthesia (p=0.035) were identified as risk factors, whereas a statistically significant
negative correlation with preoperative (p=0.001) and postoperative result (p=0.001) was proven for
age. The results indicated that a significant proportion of patients after general or regional anesthesia
developed POCD depending on patient education, CCI, COVID-19 infection, and type of anesthesia. It
was also shown that older age correlated with poorer MoCa test result independently of anesthesia. These
factors can be identified before the procedure under anesthesia, thus offering the possibility of adjusting
anesthesia and postoperative care in patients at risk of developing POCD.
Keywords
Postoperative cognitive dysfunction; Anesthesia, general, regional; MoCA test
Hrčak ID:
336241
URI
Publication date:
31.12.2024.
Visits: 513 *