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Periodicum biologorum, Vol. 127 No. 1-2, 2025.

Review article

https://doi.org/10.18054/pb.v127i1-2.35848

Reintubation in the intensive care unit: challenges,risks, and strategies for prevention

Višnja Nesek Adam ; University Department of Anesthesiology, Resuscitation and Intensive Care, Sveti Duh University Hospital, Zagreb, Croatia; Emergency Department, Sveti Duh University Hospital, Zagreb, Croatia; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; University North, Varaždin, Croatia *
Martina Matolić ; University Department of Anesthesiology, Resuscitation and Intensive Care, Sveti Duh University Hospital, Zagreb, Croatia
Điđi Delalić ; Emergency Department, Sveti Duh University Hospital, Zagreb, Croatia
Tamara Murselović ; University Department of Anesthesiology, Resuscitation and Intensive Care, Sveti Duh University Hospital, Zagreb, Croatia; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Ante Penavić ; University Department of Anesthesiology, Resuscitation and Intensive Care, Sveti Duh University Hospital, Zagreb, Croatia; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

* Corresponding author.

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Abstract

Background and purpose: Reintubation in the intensive care unit is a critical event linked to increased morbidity, prolonged hospitalization, and higher mortality. It often results from respiratory muscle weakness, airway edema, neurological impairment, or cardiovascular instability. Patients requiring reintubation face elevated risks of ventilator-associated pneumonia, airway trauma, and hemodynamic instability. Preventive strategies such as careful extubation planning, noninvasive ventilation, high-flow nasal cannula, corticosteroids for airway edema, and optimized fluid management can help reduce reintubation rates. A structured, multidisciplinary approach is essential for improving extubation success and patient outcomes.
Conclusions: This review examines the causes, risk factors, and consequences of reintubation, along with strategies for prevention and management, emphasizing the importance of evidence-based weaning protocols and advanced monitoring techniques.

Keywords

airway management; airway extubation; intensive care units; respiration, artificial; respiratory insufficiency

Hrčak ID:

340261

URI

https://hrcak.srce.hr/340261

Publication date:

1.12.2025.

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