Acta clinica Croatica, Vol. 64. No. 3, 2025.
Original scientific paper
https://doi.org/10.20471/acc.2025.64.03.10
A Novel Biomarker to Predict Contrast-Induced Nephropathy and the Requirement for Renal Replacement Therapy in Patients Undergoing Coronary Angiography: C-PEPTIDE/HBA1C
Kenan Toprak
; Harran University Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey
*
Mustafa Kaplangoray
; Sheikh Edebali University, Department of Cardiology, Bilecik, Turkey
Selahattin Akyol
; Kartal Kosuyolu High Specialization Training and Research Hospital, Department of Cardiology, İstanbul, Turkey
Mustafa Begenç Taşcanov
; Harran University Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey
İbrahim Halil Altıparmak
; Harran University Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey
Asuman Biçer
; Harran University Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey
Recep Demirbağ
; Harran University Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey
* Corresponding author.
Abstract
Contrast-induced nephropathy (CIN) is a major cause of mortality and morbidity
with an increasing incidence after coronary angiography (CAG). For this reason, it is important to
identify subjects who are prone to CIN in advance and to take intensive protective measures accordingly.
In this study, we aimed to reveal the role of C-peptide, HbA1c and C-peptide/HbA1c (CHR) ratio
for predicting CIN development and the requirement for renal replacement therapy (RRT) in patients
undergoing CAG. A total of 2,271 patients who underwent CAG between January 2019 and June 2021
were included in this prospective observational study. C-peptide and HbA1c levels were measured in all
patients who underwent CAG, whether they were diabetic or not. We attempted to identify independent
predictors for the development of CIN. In addition, patients who needed RRT after CIN were followed
up for an average of 90 days. In a multivariate analysis, CHR was determined as an independent
predictor of CIN and identified as an independent risk factor for the requirement for RRT in patients
undergoing CAG. The main finding of our study was the fact that we identified CHR as an independent
predictor for the development of CIN and the need for RRT in patients undergoing CAG.
Keywords
Contrast-induced nephropathy; Coronary angiography; C-peptide; HbA1c; Renal replacement therapy
Hrčak ID:
342936
URI
Publication date:
30.9.2025.
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