Original scientific paper

https://doi.org/10.20471/jan.2026.01.04

Phosphatidylethanol in Blood as a Marker of Alcohol Dependence

Yury Evgeny Razvodovsky orcid.org/0000-0001-7185-380X ; Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus, Grodno, Republic of Belarus *
Aleksey Vladimirovitz Schuriberco orcid.org/0000-0001-7185-380X ; Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus, Grodno, Republic of Belarus

* Corresponding author.

Abstract

Aim: To establish the cut-off value of phosphatidylethanol (PEth) concentration in the blood for detecting alcohol dependence. Materials and Methods: Using the method of high-performance liquid chromatography - tandem mass spectrometry (HPLC - MS), the concentration of PEth in the blood of 127 alcohol-dependent men undergoing hospital treatment was determined. To assess the diagnostic accuracy and to establish the cut-off values of PEth concentration, a ROC (receiver operating characteristic) analysis was performed. Statistical data processing was carried out using the Statistica 10.0 program. Results: At a cut-off PEth concentration of 495 ng/ ml, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 99 %, 96 %, 98 %, 98 % respectively. Conclusion: The results of the study indicate the high diagnostic reliability of PEth as a biochemical marker of alcohol dependence.

Keywords

Phosphatidylethanol; reference values; alcohol-related disorders

Hrčak ID:

344459

URI

https://hrcak.srce.hr/344459

Publication date:

10.2.2026.

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