Original scientific paper

https://doi.org/10.20471/acc.2026.65.02.01

The Deterioration of Different Cognitive Domains in Relation to Alzheimer’s Disease Severity: A Cross-Sectional Study

Zaim Jatić orcid.org/0000-0002-5288-7745 ; Health Center of Sarajevo Canton, Sarajevo, Bosnia and Herzegovina; Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Marnela Palameta ; Mostar Health Center, Mostar, Bosnia and Herzegovina
Elvira Hasanović ; Health Center of Sarajevo Canton, Sarajevo, Bosnia and Herzegovina
Subhija Prasko ; The Public Institution Health Center Zenica, Zenica, Bosnia and Herzegovina
Katmerka Cerić ; The Public Institution Health Center Bihać, Bihać, Bosnia and Herzegovina
Zinaida Hajrić ; The Public Institution Health Center "dr. Mustafa Šehović" Tuzla, Bosnia and Herzegovina
Aziz Šukalo ; Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina
Jasna Džananović Jaganjac ; Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina
Amna Tanović Avdić ; Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina
Meliha Mehić ; Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina
Merita Tirić Čampara ; General Hospital “Prim. dr. Abdulah Nakaš”, Sarajevo, Bosnia and Herzegovina
Amira Skopljak ; Health Center of Sarajevo Canton, Sarajevo, Bosnia and Herzegovina
Almasa Jandrić ; Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina
Una Glamočlija orcid.org/0000-0003-1206-6990 ; Bosnalijek d.d., Sarajevo, Bosnia and Herzegovina; University of Sarajevo – Faculty of Pharmacy, Sarajevo, Bosnia and Herzegovina; School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina *

* Corresponding author.

Abstract

The sequence of deterioration in different cognitive domains, depending on the
severity of Alzheimer’s disease (AD), is still largely unknown. The aim of this study
was to use the Mini–Mental State Examination (MMSE) scale to divide subjects
into six groups of disease severity and compare the deterioration in cognitive
domains (orientation in time and place, working memory, concentration, recall,
language, and visuospatial orientation) between the groups. A total of 624 participants
with a median age of 76 years (interquartile range (IQR) 70–80 years)
were included in the study. A significant difference in age was observed between
participants with severe cognitive impairment compared to other participants.
No difference in sex structure was observed between the groups. The highest
fluctuation, even in persons without cognitive impairment, was observed in the
recall and concentration domains, followed by visuospatial orientation. The first
deteriorated domains with progression of the disease were concentration and
visuospatial orientation. Deterioration then continued in orientation in time and
place, language, and working memory. The results can be used to predict the
development of the disease, as well as for the adequate planning and testing of
therapeutic approaches for AD.

Keywords

Alzheimer’s disease; Screening; Cognitive decline sequence

Hrčak ID:

347684

URI

https://hrcak.srce.hr/347684

Publication date:

10.6.2026.

Article data in other languages: croatian

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