Original scientific paper

https://doi.org/10.20471/acc.2026.65.02.13

Evaluation of the Efficacy of Photobiomodulation and Vitamin B12 for Burning Mouth Syndrome

Miao Zhang ; Department of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
Huanling Wang ; Department of Stomatology, Lushan Road Community Health Service Center, Hedong District, Tianjin, China
Yanjie Li ; Department of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
Fei Du ; Department of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
Peipei Yan ; Department of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
Ruiyang Chen ; Department of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China
Chenlu Liu ; Department of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China *

* Corresponding author.

Abstract

This study aimed to evaluate the impact of low-level laser therapy (LLLT) and
topical vitamin B12 treatment on patients with burning mouth syndrome (BMS).
A total of 123 patients were enrolled and assigned randomly into three groups:
LLLT, B12, or no-treatment. Patients completed the EuroQol Five-Dimension
Health-Related Quality-of-Life (EQ-5D-5L HRQoL) questionnaire and a visual
analog scale (VAS) both before and after treatment. The data were analyzed
using R 4.4.2 statistical software to compare pre- and post-treatment differences.
Significant differences in the post-treatment period were observed between
the three groups for pain/discomfort, anxiety/depression, and VAS scores. Both
the B12 and LLLT groups had significantly higher post-treatment scores compared
to those in the no-treatment group. Although the differences between
the B12 and LLLT groups were not statistically significant, the LLLT group had
consistently higher scores. Significant improvements were observed in the LLLT
group (P < 0.001). Similarly, pain/discomfort (P < 0.001) and anxiety/depression
(P < 0.001) improved significantly after treatment (P < 0.05) in the B12 group.
LLLT and topical vitamin B12 therapy both improved the overall systemic health
status of patients with BMS, with LLLT being more effective than topical vitamin
B12 treatment.

Keywords

Burning mouth syndrome; Low-level laser therapy; Vitamin B12; Systemic health assessment; Randomized controlled trial

Hrčak ID:

347705

URI

https://hrcak.srce.hr/347705

Publication date:

10.6.2026.

Article data in other languages: croatian

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