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Journal of Electrochemical Science and Engineering, Vol. 16 , 2026.

Original scientific paper

https://doi.org/https://doi.org/10.5599/jese.3468

Electrochemical detection of gliclazide and glibenclamide on metal organic framework/multi-walled carbon nanotubes nanocomposite modified screen printed electrode

Shatha Abd Aljabbar Ismael ; Department of Biology, College of Education for Pure Science, University of Karbala, Iraq
Hasan Ali Alsailawi ; Department of Basic Sciences, College of Density, University of Kerbala, 56001, Karbala, Iraq
Mohamed Ahmad ; Department of Physics, College of Science, University of Sumer, Iraq
Mustafa Mudhafar ; Centre for Research on Environment and Renewable Energy, University of Kerbala, Karbala, 56001, Iraq *
Hussein Ali Al-Bahari ; Department of Chemistry, College of Education for Pure Science, University of Karbala, Iraq

* Corresponding author.

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Abstract

This study presents a novel SPE modification using a Zn-Ni-based 1,4-benzene­dicarbon­xylate (BDC) metal-organic framework (MOF)/multi-walled carbon nanotubes (MWCNTs) nanocomposite (Zn-Ni-BDC MOF/MWCNTs nanocomposite) for the detection of gliclazide and glibenclamide. Several methods, including cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry, were used to characterize the modified electrode (MOF/MWCNT/SPE). On the modified electrode surface, the electrochemical characteristics of gliclazide were investigated. The MOF/MWCNT/SPE sensor's ability to electrochemically detect gliclazide and glibenclamide in aqueous solution was shown to be greatly enhanced. The improved sensor's electrocatalytic properties were further utilized to detect gliclazide using DPV. The sensor effectively resolved the overlap in the corresponding voltammetric responses and displayed two well-resolved voltammetric peaks for the two targets. According to DPV, the peak currents from gliclazide increased linearly at concentrations between 0.75 and 500 mM. Gliclazide showed a detection limit of 0.12 mM, according to the modified electrode. The provided approach was also effective in identifying two analytes in urine samples and medications.

Keywords

Diabetes treatment; sulfonylureas; electrochemical determination; chemically modified electrode; urine analysis, pharmaceutical tablets analysis

Hrčak ID:

351278

URI

https://hrcak.srce.hr/351278

Publication date:

8.7.2026.

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