Short communication, Note
https://doi.org/https://doi.org/10.5599/jese.3459
Tadalafil electrooxidation on gold and MWCNT-based nanocomposites modified carbon paste electrodes: comparative study and analytical application
Jasmina Anojčić
; University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry, and Environmental Protection, Novi Sad, Serbia
*
Sanja Mutić
; University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry, and Environmental Protection, Novi Sad, Serbia
Sanja Stevanović
; University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Electrochemistry, Njegoševa 12, 11000 Belgrade, Serbia
Nebojša D. Nikolić
; University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Electrochemistry, Njegoševa 12, 11000 Belgrade, Serbia
Dušan Mijin
; University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia
Slobodan Petrović
; University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia
Zoltán Kónya
; Department of Applied and Environmental Chemistry, University of Szeged, Rerrich Béla tér 1, 6720 Szeged, Hungary
Milka Avramov Ivić
* Corresponding author.
Abstract
The electrochemical behaviour of tadalafil (TAD) was investigated using a solid gold electrode and carbon paste electrodes (CPE) modified with multiwalled carbon nanotubes (MWCNT) or their nanocomposites with noble metal particles (Ag-MWCNT and Au-MWCNT). Cyclic voltammetric study revealed that the oxidation of TAD is irreversible and that adsorption plays a significant role in the oxidation mechanism. Among the investigated electrodes, the Au-MWCNT/CPE exhibited the best electroanalytical performance and was used to develop a sensitive and reliable square-wave adsorptive stripping voltammetric method for TAD determination in Britton-Robinson buffer solution as supporting electrolyte. The optimal pH was 4.0, with target analyte accumulation being most pronounced at Eacc = 0.6 V and tacc = 10 s. Linearity was obtained in the TAD concentration range of 0.10 to 1.96 µg mL-1, with calculated limit of detection of 0.03 µg mL-1. The constructed sensor showed excellent repeatability and reproducibility, as well as anti-interference ability, making it highly suitable for analytical applications, such as the quantification of TAD in the pharmaceutical formulation Cialis® and in human blood serum sample.
Keywords
Pharmaceuticals; electroanalysis; electrochemical sensors; voltammetry; pharmaceutical formulation; human blood serum sample
Hrčak ID:
351292
URI
Publication date:
7.7.2026.
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