Short communication, Note
https://doi.org/10.2478/10004-1254-60-2009-1893
Skin Decontamination with Mineral Cationic Carrier Against Sarin Determined In vivo
Ante Vučemilović
; Institute of Researches and Development of Defense Systems, Zagreb, Croatia
Mirko Hadžija
; Ruđer Bošković Institute, Zagreb, Croatia
Ivan Jukić
; Institute of Researches and Development of Defense Systems, Zagreb, Croatia
Abstract
Our Institute’s nuclear, biological, and chemical defense research team continuously investigates and develops preparations for skin decontamination against nerve agents. In this in vivo study, we evaluated skin decontamination efficacy against sarin by a synthetic preparation called Mineral Cationic Carrier (MCC®) with known ion exchange, absorption efficacy and bioactive potential. Mice were treated with increasing doses of sarin applied on their skin, and MCC® was administered immediately after contamination. The results showed that decontamination with MCC® could achieve therapeutic efficacy corresponding to 3 x LD50 of percutaneous sarin and call for further research.
Keywords
bioactive potential; MCC®; nerve agent; NOD mice; sorption powder; toxicity
Hrčak ID:
38395
URI
Publication date:
12.6.2009.
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