Review article

Primjena biološke varijacije - pregledni članak

Carmen Ricós ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, University Hospital Vall d'Hebron, Barcelona, Spain
Carmen Perich ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Bon Pastor, Barcelona, Spain
Joana Minchinela ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Barcelonès Nord, Badalona, Spain
Virtudes Álvarez ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Hospitalet, Hospitalet, Spain
Margarita Simón ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Hospital Anoia, Vilafranca del Penedès, Spain
Carmen Biosca ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Hospital Germans Trías i Pujol, Badalona, Spain
Mariví Doménech ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Manso, Barcelona, Spain
Pilar Fernández ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Biochemistry Department, Hospital La Paz, Madrid, Spain
Carlos-Víctor Jiménez ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Primary Care Center Barcelonès Nord, Badalona, Spain
José Vicente Garcia-Lario ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, University Hospital Virgen de las Nieves, Granada, Spain
Fernando Cava ; Analytical Quality Committee, Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC), Spain; Laboratory Department, Hospital Alcorcón Foundation, Madrid, Spain

Abstract

Ovaj rad sadrži opsežan pregled sastavnica biološke varijacije (BV), tj. intraindividualne (nasumična fluktuacija analita oko osnovne vrijednosti svakog pojedinca) i interindividualne (ukupna varijacija od osnovnih vrijednosti različitih osoba) varijacije, zatim ukratko objašnjava procjenu veličine intraindividualne i interindividualne BV u zdravih i oboljelih ispitanika, podrobno obrađuje osam složenijih primjena procjena BV, te govori o zanimljivim detaljima koji izazivaju najviše rasprava.
Cilj rada je raspraviti kako pomoću današnje tehnologije doći do specifikacija kvalitete dobivenih na temelju BV u zdravih pojedinaca te u kojim se slučajevima koristiti podacima od oboljelih ispitanika.
Konačno, u radu se promiče daljnji razvoj primjene BV, poput upozoravanja liječnika o promjenama u bolesnikovu stanju.

Keywords

biološka varijacija; specifikacije kvalitete; referentna vrijednost promjene; delta provjera; laboratorijski nalaz

Hrčak ID:

40854

URI

https://hrcak.srce.hr/40854

Publication date:

24.9.2009.

Article data in other languages: english

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