Original scientific paper
https://doi.org/10.2478/10004-1254-61-2010-1993
Protective Effects of Selenium, Calcium, and Magnesium against Arsenic-Induced Oxidative Stress in Male Rats
Deepti Srivastava
; BRD School of Biosciences, Sardar Patel University, Vallabh Vidyanagar, India
Ramlingam B. Subramanian
; BRD School of Biosciences, Sardar Patel University, Vallabh Vidyanagar, India
Datta Madamwar
; BRD School of Biosciences, Sardar Patel University, Vallabh Vidyanagar, India
Swaran J. S. Flora
; Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
Abstract
Inorganic arsenic is a potent carcinogen and environmental pollutant. More than one hundred million people are reported to be exposed to elevated concentrations of arsenic mainly via drinking water. Essential
trace elements can affect toxicity of metals by interacting with metals at the primary site of action and can also modify the body’s response to toxic metals by altering their metabolism and transport. This study
investigates the effects of concomitant administration of selenium, magnesium, and calcium with arsenic on blood biochemistry and oxidative stress. Selenium was the most effective in reducing arsenic-induced inhibition of blood δ-aminolevulinic acid dehydratase (ALAD) activity and liver oxidative stress. Calcium and magnesium also showed favourable effects on haematological and other biochemical parameters.
Because selenium was the most effective, it should be added to chelation therapy to achieve the best protective effects against arsenic poisoning in humans.
Keywords
aminolevulinic acid dehydratase; glutathione; reactive oxygen species; thiobarbituric acid reactive substances; trace elements
Hrčak ID:
53951
URI
Publication date:
16.6.2010.
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