Original scientific paper

Antioxidant activity of some (7-hydroxy-2-oxo-2H-chromen-4-yl) acetic acid derivatives

Maja Molnar ; University of Josip Juraj Strossmayer in Osijek, Faculty of Food Technology Osijek, Department of Applied Chemistry and Ecology, Franje Kuhača 20, 31000 Osijek, Croatia
M. Čačić ; University of Josip Juraj Strossmayer in Osijek, Faculty of Food Technology Osijek, Department of Applied Chemistry and Ecology, Franje Kuhača 20, 31000 Osijek, Croatia

Abstract

A series of coumarin Schiff bases (7-(arylidenehydrazinocarbonylmethoxy)-2-oxo-2H-chromen-4-yl]acetic acid arylidenehydrazide) (4a-k) and N-(2-aryl-4-oxothiazolidin-3-yl)-2-{[4-(2-aryl-4-oxothiazolidin-3-yl)carbamoylmethyl]-2-oxo-2H-chromen-7-yloxy}-acetamides (5a-k) were synthesized and evaluated for their antioxidant activity (scavenging of 1,1-diphenyl-2-picryhydrazyl radical and phosphomolybdenum method). Compounds with 3,4-dihydroxyphenyl and 2,5-dihidroxyphenyl ring showed the best 1,1-diphenyl-2-picryhydrazyl (DPPH) scavenging activity, whereas the best activity investigated by phosphomolybdenum method was found for the compounds with 2,5-dihidroxydiphenyl ring.

Keywords

coumarin; antioxidant activity; Schiff base; 4-thiazolidinone

Hrčak ID:

84724

URI

https://hrcak.srce.hr/84724

Publication date:

19.7.2012.

Visits: 2.686 *