Review article
CARDIOPROTECTION BY VOLATILE ANESTHETICS: FROM BENCH TO BEDSIDE AND BACK
Filip Sedlić
; Department of Anesthesiology, Medical College of Wisconsin, Wisconsin, USA
A Šepac
; Department of Anesthesiology, Medical College of Wisconsin, Wisconsin, USA
M Muravyeva
; Department of Anesthesiology, Medical College of Wisconsin, Wisconsin, USA
Željko Bošnjak
; Department of Anesthesiology, Medical College of Wisconsin, Wisconsin, USA
Abstract
Ischemia and reperfusion (I/R) injury of the heart can be ameliorated
by volatile anesthetics (VAs). Application of VAs prior to the ischemic
event triggers endogenous cardioprotective program that persists even after
anesthetic removal, and it is called anesthetic-induced preconditioning
(APC) (1). VAs can also reduce infarct size if applied during the reperfusion
period (anesthetic postconditioning), where they can also exert protection
by the direct effects on cardiac cells, specifically on the mitochondrial function.
In this review, authors will summarize the fundamental concepts related
to cardioprotection by VAs and implementation of research based on
animal models to clinical practice. We will specifically address the role of
human stem cell-based models in studying normal cardioprotective pathways,
and more importantly, in studying certain diseases, such as diabetes
mellitus that negatively affect APC.
Keywords
Hrčak ID:
70921
URI
Publication date:
27.5.2011.
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