Original scientific paper
Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid
Lakshmy Ramachandran
; Amala Cancer Research Centre, Indi
Cherupally Krishnan Krishnan Nai
; Pushpagiri Institute of medical sciences & Research Centre, India
Abstract
Silver (SN) nanoparticles were re‐dispersed in
aqueous solution of Pluronic F127 and complexed with
the antioxidant, alpha‐ Lipoic acid (LA). The nanoparticle
‐ LA complex (SN‐LA) was characterized using SEM. SN‐
LA exhibited DPPH radical scavenging activity in vitro
and anti‐ inflammatory activity against acute and chronic
paw models of edema in mice. SN‐LA protected mice
from whole body gamma radiation induced body weight
losses and mortality revealing its radioprotecting
capacity. Meanwhile, SN‐LA administration to tumour‐
bearing mice prior to whole body gamma radiation
exposure, aided in better tumour growth delay. The
results suggest the feasibility in using SN‐LA as a
therapeutic adjuvant during cancer radiotherapy.
Keywords
silver nanoparticle; lipoic acid; anti‐ inflammatory; anti tumor; radiotherapy
Hrčak ID:
72509
URI
Publication date:
15.9.2011.
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