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Biochemia Medica, Vol. 21 No. 3, 2011.

Other

Molecular pathways in cancer-related inflammation

Annalisa Dep Prete orcid id orcid.org/0000-0002-3738-412X ; Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Basic Medical Sciences, University of Bari, Bari, Italy
Paola Allavena ; Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Giuseppe Santoro ; Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy
Ruggiero Fumarulo ; Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy
Massimiliano M. Corsi ; Department of Human Morphology and Biomedical Sciences “Città Studi”, University of Milan, and Soc. Clinical Pathology and IRCCS Policlinico San Donato, Milan, Italy
Alberto Mantovani ; Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Translational Medicine, University of Milan, Milan, Italy

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Abstract

Accumulating evidence shows that chronic inflammation is associated to increased risk of cancer. An inflammatory component is present also in the microenvironment of tumours epidemiologically unre-lated to inflammation. Extensive investigations over the past decade have uncovered many of the important mechanistic pathways underlying cancer-related inflammation. Pathways linking inflamma-tion and cancer have been identified: an intrinsic one (driven by genetic events that cause neoplasia) and an extrinsic one (driven by inflammatory conditions which predispose to cancer). Smouldering inflammation is a component of the tumour microenvironment and is a recognized hallmark of cancer. Key orchestrators at the intersection of the intrinsic and extrinsic pathways include transcription fac-tors (e.g. Nuclear Factor kappa-B, NFκB) that modulate the inflammatory response through soluble mediators (cytokines, chemokines) and cellular components (e.g. tumor-associated macrophages), promoting tumorigenesis. NFκB aids in the proliferation and survival of malignant cells, promotes an-giogenesis and metastasis, subverts adaptive immunity, and alters responses to hormones and che-motherapeutic agents. Emerging evidence also suggests that persistent inflammation promotes ge-netic instability. Thus, cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies.

Keywords

cancer-related inflammation; cytokines; chemokines; macrophages

Hrčak ID:

72947

URI

https://hrcak.srce.hr/72947

Publication date:

15.10.2011.

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