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Food Technology and Biotechnology, Vol. 49 No. 4, 2011.

Original scientific paper

Demethylation of N,N-Dimethylbenzenamine and N,N,3-Trimethylbenzenamine by Whole Cells of Aspergillus terreus

Leandro Piovan ; Institute of Chemistry of Săo Paulo, University of Săo Paulo, Av. Prof. Lineu Prestes, 748, CEP 05508-900, Săo Paulo-SP, Brazil
Edna Kagohara ; Institute of Chemistry of Săo Paulo, University of Săo Paulo, Av. Prof. Lineu Prestes, 748, CEP 05508-900, Săo Paulo-SP, Brazil
Juliana Alves Vale ; Institute of Chemistry of Săo Paulo, University of Săo Paulo, Av. Prof. Lineu Prestes, 748, CEP 05508-900, Săo Paulo-SP, Brazil
João Valdir Comasseto ; Institute of Chemistry of Săo Paulo, University of Săo Paulo, Av. Prof. Lineu Prestes, 748, CEP 05508-900, Săo Paulo-SP, Brazil
Iracema Helena Schoenlein-Crusius ; Institute of Botany of Săo Paulo, Section of Mycology and Lichenology, Av. Miguel Stéfano, 3687, CEP 01061-970, São Paulo-SP, Brazil
Leandro Helgueira Andrade ; Institute of Chemistry of Săo Paulo, University of Săo Paulo, Av. Prof. Lineu Prestes, 748, CEP 05508-900, Săo Paulo-SP, Brazil
André Luiz Meleiro Porto ; Institute of Chemistry of Săo Carlos, University of Săo Paulo, Av. Trabalhador Săo-Carlense, 400, CEP 13566-590, Săo Carlos-SP, Brazil

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Abstract

N,N-dimethylbenzenamine and N,N,3-trimethylbenzenamine were N-demethylated through enzymatic reactions mediated by whole cells of Aspergillus terreus strains SSP 1498, URM 3371 and URM 3571. The respective products, N-methylbenzenamine and N,3-dimethylbenzenamine, were obtained in high conversions under both neutral and basic conditions. The oxidative N-demethylation of tertiary aromatic amines by A. terreus was not enhanced by the presence of the oxidant tert-butylperoxide, although further demethylation of N,N-dimethylbenzenamine to aniline was observed. The strains of the investigated A. terreus were unable to perform the dealkylation of N,N-diethylbenzenamine.

Keywords

Aspergillus terreus; N-demethylation; tertiary aromatic amines; biotransformation

Hrčak ID:

75184

URI

https://hrcak.srce.hr/75184

Publication date:

20.12.2011.

Article data in other languages: croatian

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