Review article

Cytomorphologic diagnostics of acute myeloid leukemia – the World Health Organization classification

Sunčica Ries ; Klinički zavod za patologiju i citologiju, KBC Zagreb, Zagreb, Hrvatska

Abstract

World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues incorporates morphologic, cytochemical, immunophenotypic, genetic and clinical informations into diagnostic algorithms for myeloid neoplasms. Cytomorphologic assessment of more than 20% blasts from 200-cell leukocyte differential counts of the peripheral blood smear and 500-cell differential counts of all cells in the bone marrow aspirate stained with May-Gruenwald Giemsa (MGG), is considered to be an acute leukemia. Along with cytomorphologic findings, the diagnosis is established with immunophenotypic, genetic and molecular findings, but clinical factors must be taken into consideration when deciding the onset of therapy.

Keywords

acute myeloid leukemia; cytomorphology; WHO

Hrčak ID:

76666

URI

https://hrcak.srce.hr/76666

Publication date:

1.12.2011.

Article data in other languages: croatian

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