Paediatria Croatica, Vol. 56 No. 2, 2012.
Professional paper
ASSOCIATION BETWEEN PLASMINOGEN ACTIVATOR INHIBITOR-1 AND METHYLENTETRAHYDROFOLATE REDUCTASE POLYMORPHISM WITH INCREASED HOMOCYSTEINE LEVELS IN A 14-YEAR-OLD GIRL WITH ISCHEMIC STROKE
Tena Trbojević
; Medicinski fakultet Sveučilišta u Zagrebu
Martina Rastovac
Lea Miklić
Branka Bunoza
Goran Tešović
Ernest Bilić
Nina Barišić
; KBC Zagreb
Abstract
We present a 14-year-old girl with ischemic stroke in the right middle cerebral artery territory, associated with polymorphism 4G/4G plasminogen activator inhibitor-1 (PAI-1:genotype 4G/4G) and homozygous genotype C677T for methylentetrahydrofolate reductase with consequential hyperhomocysteinemia. In the initial phase, clinical presentation and laboratory results indicated acute disseminated encephalomyelitis and i.v. globulins and plasmapheresis were carried out. Control MRI with angiography showed a post-ischemic lesion after occlusion of the right internal carotid artery. Analysis of prothrombotic disorders and association with the acquired disorders are significant on evaluating the etiology of ischemic stroke in children. This case shows the variability of etiological inherited and acquired factors in children with stroke and complicated clinical course, which can correspond to acute disseminated encephalomyelitis in the acute phase and also points to the importance of identifying the cause for the possible secondary stroke prevention.
Keywords
Descriptors: STROKE – diagnosis, therapy; POLYMORPHISM, GENETIC; HOMOCYSTEINE; ADOLESCENT; PLASMINOGEN ACTIVATOR INHIBITOR 1
Hrčak ID:
87283
URI
Publication date:
25.6.2012.
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