Original scientific paper
https://doi.org/10.2478/10004-1254-63-2012-2241
Two Rare Cases of Central Nervous System Opportunistic Mycoses
Emilija Mlinarić Missoni
; Reference Centre for Mycological Diagnostics of Systemic and Disseminated Infections, Croatian National Institute of Public Health, Zagreb, Croatia
Bruno Baršić
; University Hospital for Infectious Diseases2, University of Zagreb School of Medicine, Zagreb, Croatia
Abstract
This article presents two cases of opportunistic mycoses (OMs) of the central nervous system (CNS) caused by Cryptococcus neoformans and Aspergillus nidulans, respectively. The patients were hospitalised in local hospitals between 2009 and 2011 because of unspecific symptoms (fever, headache, and/or weight lost). Duration of symptoms varied from 4 days to over 2 weeks. The patients were treated with antibiotics and symptomatically. OM was not suspected in any of them. The patients became critically ill with symptoms of CNS involvement and were transferred to the Intensive Care Unit (ICU) of the University Hospital for Infectious diseases (UHID) in Zagreb. None of the patients belonged to the high-risk population for developing OMs. They were not HIV-infected, had no transplantation of bone marrow or solid organ, and were not on severe immunosuppressive chemotherapy. Fungi were isolated from cerebrospinal fluid (CSF) samples and, in one patient, from aspirate of cerebral abscess. Isolation and mycological identifi cation of all fungal isolates and in vitro antifungal susceptibility testing of these isolates were done at the Reference Centre for Mycological Diagnostics of Systemic and Disseminated Infections (RCMDSDI) in Zagreb. The patient with cryptococcal meningitis was treated with amphotericin B and fl uconazole and the patient with cerebral aspergilloma with voriconazole.
Keywords
Aspergillus nidulans; CNS; Cryptococcus neoformans
Hrčak ID:
93660
URI
Publication date:
14.12.2012.
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