Original scientific paper

Effects of Alpha-MSH on Corneal Epithelial Lesions in Rats

Josip Pavan ; University of Zagreb, Dubrava University Hospital, Department of Ophthalmology, Zagreb, Croatia
Adrian Lukenda ; University of Zagreb, Dubrava University Hospital, Department of Ophthalmology, Zagreb, Croatia
Nikola Stambuk ; »Rudjer Bo{kovic« Institute, Zagreb, Croatia
Pasko Konjevoda ; »Rudjer Bo{kovic« Institute, Zagreb, Croatia
Snjezana Kastelan ; University of Zagreb, Dubrava University Hospital, Department of Ophthalmology, Zagreb, Croatia
Marko Curkovic ; University of Zagreb, Dubrava University Hospital, Department of Ophthalmology, Zagreb, Croatia

Abstract

We investigated the influence of alpha-melanocyte stimulating hormone (a-MSH) on the healing of corneal epithelial lesions in male Wistar rats. The lesions were induced by abrading corneal epithelium with a surgical lancet under a biomicroscope. Before the abrasion corneal epithelium was softened with 40% ethanol. a-MSH drops in a concentration of 1×10–4 mg/mL significantly promoted epithelial healing, when compared to the control group treated with 0.9% NaCl. Significant reduction of ocular irritation was also observed. Topical a-MSH medication could promote the healing of corneal wounds and reduce local inflammatory response without the major side effects of the corticosteroid therapy.

Keywords

alpha-MSH; cornea; drops; epithelization; wound; healing; irritation

Hrčak ID:

94982

URI

https://hrcak.srce.hr/94982

Publication date:

27.12.2012.

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