Original scientific paper
Cytotoxicity of Ca(OH)2 Endodontic Sealers on Connective, Muscle and Bone Tissues
Dunja Buntak-Kobler
; Department of Dental Pathology - School of Dentistry University of Zagreb, Croatia
Goranka Prpić-Mehičić
; Department of Dental Pathology - School of Dentistry University of Zagreb, Croatia
Dora Najžar-Fleger
; Department of Dental Pathology - School of Dentistry University of Zagreb, Croatia
Marina Katunarić
; Department of Dental Pathology - School of Dentistry University of Zagreb, Croatia
Jasna Talan-Hranilović
; Ljudevit Jurak Department of Pathology »Sestre Milosrdnice« - University Hospital Institute Ruder Bošković, Zagreb
Lidija Šuman
; Ljudevit Jurak Department of Pathology »Sestre Milosrdnice« - University Hospital Institute Ruder Bošković, Zagreb
Abstract
Among numerous root canal sealers those on the basis of Ca(OH)2 are used too. The purpose of this study was to examine possible toxic impact of sealers based on Ca(OH)2 (Sealapex, Kerr and Apexit, Vivadent) on the connective tissue, muscle, bone and cartilage, and compared the results with the impact o f sealers based on the polyketonic compound (Diaket, ESPE). In our experiment 52 female mice of the C-57 BLI6 breed were used. 0.5 ccm of the sealer was injected subcutaneously into the tail root of the laboratory animals.
This experimental model was elected due to this location all the examined structures were present. The control group was injected
Hanks. The test period was 2, 8 and 30 days respectively, and the sealers impact was histologically examined. After eight days period, the most severe inflammation develops in Sealapex-injected group. After 30 days period in Apexit group, the mildest inflammatory reaction was found. The results indicated Apexit to be the mildest irritant and it had not penetrated into the deeper layers of the tissue.
Keywords
Ca(OH)2; endodontic sealers; cytotoxicity
Hrčak ID:
99923
URI
Publication date:
15.9.1993.
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