Professional paper

Osteogenesis imperfecta - pamidronate treatment in Split Clinical Hospital Centre

Ankica Kragić ; KBC Split, Odjel za nuklearnu medicinu
Goran Mijaljica ; Medicinski fakultet Sveučilišta u Splitu
Zdravka Rakuljić ; Medicinski fakultet Sveučilišta u Splitu
Neven Pavlov ; KBC Split, Klinika za dječje bolesti, Klinički odjel dječje pulmologije i kardiologije
Jasminka Pavelić ; Institut "Ruđer Bošković"
Vida Čulić orcid.org/0000-0003-1352-4914 ; KBC Split, Klinika za dječje bolesti, Klinički odjel dječje pulmologije i kardiologije

Abstract

Osteogenesis imperfecta or brittle bone disease is a clinical, biochemical and genetical heterogeneous disorder of the connective tissue. Fragile and osteoporotic bones are its main feature. From 2002-2010 seven girls and six boys were treated at CHC Split. Based on clinical symptoms, they all had OI, eight of them had type I, two type III and the rest type V, VI and VII respectively. Eight of them were treated with intravenous application of pamidronate. This treatment increased bone density and reduced the incidence of fractures. To all of them we strongly recommended food rich in calcium and vitamins. Ten children undertook physical therapy and three had surgical procedures to correct their deformities. Pamidronate treatment abolished the occurrence of bone fractures and reduced pain in all treated children, along with the increase of bone mineral density, but without side effects caused by the drugs. In this treatment of OI, a multidisciplinary approach is
crucial. The cooperation of pediatricians – geneticists with children's surgeons, specialists in physical medicine and rehabilitation, and other specialists is very important. At CHC Split, special attention is needed for monitoring and educating children and parents on the nature of the disease and adequate rehabilitation after fracture.

Keywords

osteogenesis imperfecta; osteoporosis; pamidronate; treatment; desintometry

Hrčak ID:

100571

URI

https://hrcak.srce.hr/100571

Publication date:

23.4.2013.

Article data in other languages: croatian

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