Review article
Recent Advances in the Biocatalytic Asymmetric Reduction of Acetophenones and α.β-Unsaturated Carbonyl Compounds
J. Augusto R. Rodrigues
; Institute of Chemistry, State University of Campinas, CP 6154, 13084-971, Campinas, SP, Brazil
Paulo J. S. Moran
; Institute of Chemistry, State University of Campinas, CP 6154, 13084-971, Campinas, SP, Brazil
Gelson J. A. Conceição
; Faculty of Zootechny and Food Engineering, University of São Paulo, 13635-000, Pirassununga, SP, Brazil
Lucídio C. Fardelone
; Cristália Chemical and Pharmaceutical Products, 13970-970, Itapira, SP, Brazil
Abstract
Whole cells of living organisms, mainly of yeasts, have been used as reliable biocatalysts by synthetic organic chemists to perform redox reactions of various functional groups. This review focuses on the potential of these whole cells to reduce acetophenones and α.β-unsaturated carbonyl compounds (aldehydes and ketones) furnishing relevant chiral building blocks for fine chemicals and the pharmaceutical industries.
Keywords
biocatalysis; oxidoreductase; acetophenones; chiral building blocks
Hrčak ID:
110884
URI
Publication date:
15.12.2004.
Visits: 1.740 *