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Influence of Hydrogencalcium Salts of Oxidized Cellulose on MMP-2, MMP-9 and TNF-α Production and Wound Healing in Non-Healing Wounds
Jana Frankova
; Palacký University, Olomouc Faculty of Medicine and Dentistry
Dominika Diamantova
Jana Vrbkova
Jitka Ulrichova
Abstract
Levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tumour necrosis factor-α (TNF-α) may influence wound healing in non-healing wounds and wound closure. The aim of the study was to test the hypothesis that the hydrogencalcium salts of oxidised cellulose change the production of matrix metalloproteinase (MMPs) and TNF-α, wound size and number of bacterial strains in non-healing wounds. We analyzed MMP-2, MMP-9 and TNF-α in the wound fluid from 20 patients by ELISA every fourteens days over six weeks. Wound size, pain, wound closure and bacterial strains in the wound were also investigated. The wound size was reduced at 14 patients and pain in 16 patients. Bacterial contamination of the wound was significantly decreased after treatment. The level of MMP-2 correlated with TNF-α production. The level of MMP-9 was unchanged during the healing period. We concluded that thehydrogencalcium salts of oxidised cellulose have positive effect on reduction of bacterial contamination, wound size and pain.
Keywords
MMP-2; MMP-9; TNF-α; chronic wound; oxidised cellulose
Hrčak ID:
115993
URI
Publication date:
13.1.2014.
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