Original scientific paper
Gigantocellular granuloma and hiper parathyreoidism
Goran Knežević
; Zavod za oralnu kirurgiju Stomatološkog fakulteta, Zagreb
Marijo Bagatin
; Klinika za kirurgiju čeljusti, lica i usta Medicinskog i Stomatološkog fakulteta
Abstract
Presentation is made of the case of a 47-year-old male patient sub-mitted to surgery because of a gigantocellular granuloma of the upper jaw which was the only clinical sign of primary hyperparathyroidism. The formation was removed surgically due to the following reasons: pathohistologic diadnosis (tumor gigantocellularis), lesion growth of short duration (two months) and the size of the lesion (the size of a small apple). At that time laboratory analyses for hyperpa- rathyrodism had not been performed and, thus, the final diagnosis was made two months later when the patient was admitted again for a surgical closure of the naso-oral communication which had remained in the fornix after the first surgery. Then the pathohistologic diagnosis of the suspect recurrence in the palate was: granuloma gi- gantocellulare. The patient had nausea, malaise, dryness of the mouth, pain in the epigastrium, vomiting, he was losing weight and his laboratory findings showed high serum and urine calcium values
and high urine alkaline phosphatase levels. When the diagnosis of primary hyperparathyroidism was confirmed, his parathyroid adenoma was removed. The authors pose the question whether a surgical in-tervention in such lesions of the jaw is necessary, or they would un-dergo spontaneous regression following parathyroidectomy. They also compare this case with earlier investigations of the gigantocellular lesions of the jaw which were conducted to detect unrecorded cases of hyperparathyroidism. Although the results of those investigations were negative, they conclude that in cases of gigantocellular lesions of the jaw routine laboratory analyses for hyperparathyroidism are indispensable. A surgical intervention in lesions due to endocrine causes is warranted, as their spontaneous regression is a long-lasting process.
Keywords
Granuloma gigantocellularis and hiperparathyroidism
Hrčak ID:
117654
URI
Publication date:
15.6.1985.
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