Professional paper

Antisynthetase syndrome - a case report

Višnja Prus ; Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia
Dražen Bedeković ; Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia
Jasminka Milas-Ahić ; Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia
Roberta Višević ; Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia
Branko Šegec ; Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia
Zlatica Jukić ; Department for Dermatovenereology, Clinic for Dermatology and Venereology, Clinical Hospital Centre Osijek, Osijek, Croatia
Ljiljana Perić ; Clinic for Infectology, Clinical Hospital Centre Osijek, Osijek, Croatia

Abstract

Twenty-eight year-old woman with predominant signs of polymyositis, pulmonary interstitium involvement and with positive anti-Jo1 antibodies was suspected for antisynthetase syndrome. Over the next three months sores and ulcerations have appeared at the fingertips. In the later course of the disease clinical picture of mixed connective tissue disease associated with interstitial lung disease, with a dominant picture of systemic sclerosis have emerged. She was treated with glucocorticoides and immunosuppressive therapy. Patient condition was mostly stable, without significant progression of lung lesions. Early diagnosis and treatment antisynthetase syndrome significantly contributes to more favorable course and outcome of disease. A prerequisite for that are well-defined diagnostic criteria and an appropriate choice of treatment.

Keywords

antisynthetase syndrome; polymyositis; dermatomyositis; mixed connective tissue disease; anti-Jo1 antibody

Hrčak ID:

123594

URI

https://hrcak.srce.hr/123594

Publication date:

1.6.2013.

Article data in other languages: croatian

Visits: 3.220 *