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Reumatizam, Vol. 55 No. 1, 2008.

Original scientific paper

Diagnostic and therapeutic approach to pregnant women suspect on antiphospholipid syndrome

Marija Glasnović ; Clinical Department for Rheumatology, Immunology and Allergology, Clinic for Internal Medicine, Clinical Hospital Osijek, Osijek, Croatia
Ivica Bošnjak ; Clinical Department for Heart and Vascular Diseases with Intensive Treatment, Clinic for Internal Medicine, Clinical Hospital Osijek, Osijek, Croatia
Aleksandar Včev ; Clinical Department for Gastroenterology, Clinic for Internal Medicine, Clinical Hospital Osijek, Osijek, Croatia
Maja Košuta ; Department for Gynecology and Obstetrics, Clinical Hospital Osijek, Osijek, Croatia
Bahrija Lenz ; Department for Transfusion Medicine, Clinical Hospital Osijek, Osijek, Croatia
Elizabeta Glasnović-Horvatić ; Department for Pathologic Anatomy, General Hospital “dr. Tomislav Bardek”, Koprivnica, Croatia

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Abstract

Antiphospholipid syndrome includes the presence of antiphospholipid antibodies, vascular thrombosis and reproductive function disturbances. The aim was to show our diagnostic and therapeutic experiences. 62 women were included in study, 32 with primary antiphospholipd syndrome (PAPS), and 30 with secondary antiphospholipid syndrome (SAPS). 36 were pregnant and studied prospectively throughout pregnancy and six weeks after the delivery. Lupus-anticoagulant (LA) was positive in 23 patients with PAPS (71.9%), and in 10 patients with SAPS (33.3%). In SAPS group anticardiolipin antibodies (aCL) was positive in 8 patients (26.6%) compared to PAPS group with 3 aCL positive patients (9.4%). Antibeta2glycoprotein1 (antiβ2GP1) was positive in 3 patients with PAPS. Complications in previous pregnancies were in 25 cases (69.4%) spontaneous abortion, in 7 cases (19.4%) preeclampsia with intrauterine growth restriction (IUGR) in 3 patients. In 4 cases the complication was fetal death in utero. Average pregnancy lasted 37,06±0,707 weeks. Therapy with low dose aspirin and low-molecular-weight heparin was successful in 97.2%.

Keywords

antiphospholipid syndrome; pregnant women; antibodies

Hrčak ID:

125314

URI

https://hrcak.srce.hr/125314

Publication date:

1.7.2008.

Article data in other languages: croatian

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