ADMET and DMPK, Vol. 2 No. 3, 2014.
Short communication, Note
https://doi.org/10.5599/admet.2.3.123
Electrochemistry of redox-active Mn porphyrin-based SOD mimic MnTnBuOE-2-PyP5+ - Study of Redox Species Involved in ROS/RNS Scavenging
Tin Weitner
orcid.org/0000-0003-4132-2295
; 1University of Zagreb, Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, Zagreb 10000, Croatia
Ines Batinić-Haberle
; Department of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, USA
Abstract
Manganese ortho tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, is a third-generation redox-active compound currently undergoing preclinical exploration. This work is intended to complement the already extensive research of its chemical and biological properties by a simple electrochemical study. The thermodynamic parameters related to the Mn(IV) porphyrin species of MnTnBuOE-2-PyP5+ determined in this work support its observed reactivity as an efficient scavenger of peroxynitrite. The corresponding driving forces for the possible single-electron or two-electron reductions of ONOO- have been estimated as well.
Keywords
metalloporphyrins; oxidative stress; superoxide; peroxynitrite; cyclic voltammetry
Hrčak ID:
127042
URI
Publication date:
16.9.2014.
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