Acta Pharmaceutica, Vol. 65 No. 2, 2015.
Review article
https://doi.org/10.1515/acph-2015-0019
Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment
HANQING LIU
; School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China
ZHIGANG TU
; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China
FAN FENG
; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China
HAIFENG SHI
; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China
KEPING CHEN
; Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China
XIMING XU
; School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China
Abstract
A virosome is an innovative hybrid drug delivery system with advantages of both viral and non-viral vectors. Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. Targeted drug delivery using virosome-based systems can be achieved through surface modifications of virosomes. A number of virosome-based prophylactic and therapeutic products with high safety profiles are currently available in the market. Cancer treatment is a big battlefield for virosome-based drug delivery systems. This review provides an overview of the general concept, preparation procedures, working mechanisms, preclinical studies and clinical applications of virosomes in cancer treatment.
Keywords
virosome; drug delivery system; cancer treatment; cancer vaccine
Hrčak ID:
128998
URI
Publication date:
30.6.2015.
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