Original scientific paper
Polarimetric Detection of Enantioselective Adsorption by Chiral Au Nanoparticles – Effects of Temperature, Wavelength and Size
Nisha Shukla
; Institute of Complex Engineered Systems, Carnegie Mellon University, Pittsburgh, PA, USA
Nathaniel Ondeck
; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
Nathan Khosla
; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
Steven Klara
; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
Alexander Petti
; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
Andrew Gellman
; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
Abstract
R- and S-propylene oxide (PO) have been shown to interact enantiospecifically with the chiral surfaces of Au nanoparticles (NPs) modified with D- or L-cysteine (cys). This enantiospecific interaction has been detected using optical polarimetry measurements made on solutions of the D- or L-cys modified Au (cys/Au) NPs during addition of racemic PO. The selective adsorption of one enantiomer of the PO onto the cys/Au NP surfaces results in a net rotation of light during addition of the racemic PO to the solution. In order to optimize the conditions used for making these measurements and to quantify enantiospecific adsorption onto chiral NPs, this work has measured the effect of temperature, wavelength and Au NP size on optical rotation by solutions containing D- or L-cys/Au NPs and racemic PO. Increasing temperature, decreasing wavelength and decreasing NP size result in larger optical rotations.
Keywords
chiral; nanoparticle; enantioselective; adsorption; separation; Au
Hrčak ID:
142406
URI
Publication date:
1.1.2015.
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