Review article

https://doi.org/10.5599/admet.3.3.173

Assessing Blood Brain Barrier Permeability in Traumatic Brain Injury Research

George P. Liao ; Department of Pediatric Surgery, University of Texas Health Science Center at Houston , 6431 Fannin Street, MSB 5.230, Houston, TX 77030, USA
Benjamin M. Aertker ; Department of Pediatric Surgery, University of Texas Health Science Center at Houston , 6431 Fannin Street, MSB 5.230, Houston, TX 77030, USA
Daniel J. Kota ; Department of Pediatric Surgery, University of Texas Health Science Center at Houston , 6431 Fannin Street, MSB 5.230, Houston, TX 77030, USA
Karthik S. Prabhakara ; Department of Pediatric Surgery, University of Texas Health Science Center at Houston , 6431 Fannin Street, MSB 5.230, Houston, TX 77030, USA
Philippa Smith ; Department of Pediatric Surgery, University of Texas Health Science Center at Houston , 6431 Fannin Street, MSB 5.230, Houston, TX 77030, USA
Robert A. Hetz ; Department of Pediatric Surgery, University of Texas Health Science Center at Houston , 6431 Fannin Street, MSB 5.230, Houston, TX 77030, USA
Hasen Xue ; Department of Pediatric Surgery, University of Texas Health Science Center at Houston , 6431 Fannin Street, MSB 5.230, Houston, TX 77030, USA
Supinder Bedi ; Department of Pediatric Surgery, University of Texas Health Science Center at Houston , 6431 Fannin Street, MSB 5.230, Houston, TX 77030, USA
Scott D. Olson ; Department of Pediatric Surgery, University of Texas Health Science Center at Houston , 6431 Fannin Street, MSB 5.230, Houston, TX 77030, USA
Charles S. Cox Jr ; Department of Pediatric Surgery, University of Texas Health Science Center at Houston , 6431 Fannin Street, MSB 5.230, Houston, TX 77030, USA

Abstract

The blood brain barrier plays an important role in traumatic brain injury, serving at the crossroads of secondary injury and potential therapies. In regards to trauma, this barrier contains an array of cellular and molecular components that protect the central nervous system from derangements in water homeostasis and inflammation. Preclinical and clinical assays have been developed to describe and quantify blood brain barrier permeability in relation to the integrity of these blood brain barrier components and the handling of edema. This review will discuss both preclinical and clinical molecular and imaging techniques that are used to assess blood brain barrier function and recovery following traumatic brain injury.

Keywords

Extravasation; MRI; Alexa Fluor; Evans Blue; Edema

Hrčak ID:

144272

URI

https://hrcak.srce.hr/144272

Publication date:

5.9.2015.

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