ADMET and DMPK, Vol. 3 No. 3, 2015.
Review article
https://doi.org/10.5599/admet.3.3.194
Chemical and Physical Approaches for the Treatment of Alzheimer's Disease
Jing Li
; Faculty of Health Science s , University of Macau, Macau, China
Wei Zhou
; Faculty of Health Science s , University of Macau, Macau, China
Xiaoli Wu
; Faculty of Health Science s , University of Macau, Macau, China
Kin Tam
; Faculty of Health Science s , University of Macau, Macau, China
Abstract
Alzheimer’s disease (AD) is a destructive neurodegenerative disorder, which threatens elderly people in their mental health irreversibly, causing cognitive deficit such as learning difficulties and memory loss. Neurobiological pathogenesis leading to the neuronal dysfunction in AD are mainly rationalized by two hypotheses: 1) extracellular aggregation of the β-amyloid (Aβ) peptide, which impacts on the normal neuronal pathways through excessive oxidative stress and damages neurons; and 2) intracellular hyperphosphorylation of tau protein, which forms the paired helical filaments, then gravely impacts axonal transport. In this review, we firstly introduce the neurobiological concept of AD, and its pathogenesis. Then we review the chemical approaches pointedly directing at Aβ peptide and tau protein, and the clinical reality of these pharmacological strategies. Thirdly, we discuss a physical approach, deep brain stimulation (DBS), which is receiving considerable attention in recent years due to its success in treating Parkinson disease clinically. DBS delivers current pulses, which are generated by a implanted pacemaker, through electrodes into dysfunctional brain structures to influence neural activities with the possibility to improve the cognitive function. We will summarize the clinical applications of DBS to restore cognitive impairments due to AD, and animal studies related with DBS. Finally, we will discuss the current study obstacles and future research development of DBS in preclinical and clinical investigations of AD.
Keywords
Alzheimer’s disease; neurobiological pathogenesis; β-amyloid peptide; tau protein; pharmacological strategies; deep brain stimulation
Hrčak ID:
144303
URI
Publication date:
5.9.2015.
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