Case report

Reactive and Clonal Thrombocytosis: Cytokines and Acute Phase Reactants

Ljiljana Fodor-Alagić
Vladimir Stančić
Petar Gaćina
Dubravka Čaržavec
Vjeran Nikolić-Heitzler
Danijel Planinc
Krešimir Štambuk
Ivan Bonić
Boris Car
Miljenko Solter
Mira Vitezić-Misjak
Branko Bečejac
Velimir Altabas

Abstract

Platelets are acute phase reactants that increase in response to various stimuli, including systemic infections, inflammatory conditions, bleeding, and tumors. This is called reactive or secondary thrombocytosis, which is a benign form of thrombocytosis. Clonal thrombocytosis is an unregulated abnormality of platelet production due to clonal expansion of bone marrow progenitor cells. Secondary thrombocytosis may be due to the overproduction of proinflammatory cytokines such as interleukin-1 (IL-1), IL-6, and IL-11, which occurs in chronic inflammatory, infectious and malignant states. The presence of elevated IL-1, IL-6, C-reactive protein and granulocyte-macrophage colony-stimulating factor in individuals with this condition suggests that these cytokines may be involved in reactive thrombocytosis.

Keywords

Thrombocytosis - classification; Thrombocytosis - etiology; Thrombocytosis - blood; Thrombocytosis - diagnosis

Hrčak ID:

14449

URI

https://hrcak.srce.hr/14449

Publication date:

1.3.2004.

Article data in other languages: croatian

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