Original scientific paper

https://doi.org/10.18047/poljo.21.1.sup.10

GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLE

Gábor Mészáros orcid.org/0000-0002-5937-0060 ; University Of Natural Resources and Life Sciences, Vienna, Division of Livestock Sciences, Augasse 2-6, 1090, Vienna, Austria
Martin Peter Stückler ; University Of Natural Resources and Life Sciences, Vienna, Division of Livestock Sciences, Augasse 2-6, 1090, Vienna, Austria
Maja Ferenčaković ; University of Zagreb, Department of Animal Science, Svetošimunska 25, HR-10000 Zagreb, Croatia
Johann Sölkner orcid.org/0000-0002-1517-5829 ; University Of Natural Resources and Life Sciences, Vienna, Division of Livestock Sciences, Augasse 2-6, 1090, Vienna, Austria

Abstract

Runs of homozygosity (ROH) and genome wide association study (GWAS) were used to identify genomic regions of entropion in Austrian Fleckvieh cattle. Entropion is an eye disorder where the eye lids turn inward, causing inflammations, cornea damage or even blindness if left untreated. A total of 196 bulls genotyped by BovineSNP50 BeadChip were analysed, nine of which had the disorder confirmed by a veterinarian, ten were unconfirmed and 177 were healthy control animals. Runs of homozygosity analysis highlighted regions on seven chromosomes where the proportion of animals in ROH significantly (p<0.001) differed between cases and controls. None of the 19 genes identified in these regions showed any connection to entropion or eye development. The GWAS study using only cases and controls had a mild peak directly on top of the ITGA9 gene. This gene was previously identified in mice affecting cornea and eye lid development, therefore we consider it being a candidate to influence entropion also in cattle.

Keywords

cattle; SNP; GWAS; runs of homozygosity; eye disorder

Hrčak ID:

150611

URI

https://hrcak.srce.hr/150611

Publication date:

2.9.2015.

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