Short communication, Note

A protective effect of zinc in chromium poisoned rats

B. Hrabač ; Institut za patološku fiziologiju i Institut za patologiju,Medicinski fakultet, Sarajevo, Bosna i Hercegovina
S. Radović ; Institut za patološku fiziologiju i Institut za patologiju,Medicinski fakultet, Sarajevo, Bosna i Hercegovina

Abstract

The effect of a toxic trivalent chromium dose on histopathological changes in rat organs was investigated. To evaluate a protective effect of zine, rats were treated with ZnCl2 two hours before chromium administration. The protective zine action was best observed in respect to morphological changes in the organs of chromium poisoned rats, particularly in the liver. The lack of areas of focal necrosis on the liver capsule in the protected group of rats was the most evident macroscopie finding. The histopathological changes observed were in accordance with the results of own previous investigation of the changes in lactate dehydrogenase activity in rat organs induced by chromium and zine. The mechanisms of the zine protective effect against chromium poisoning are discussed.

Keywords

zine chloride; rat's organs; histopathological changes; poisoning therapy; toxic dose; trivalent chromium

Hrčak ID:

150986

URI

https://hrcak.srce.hr/150986

Publication date:

3.9.1991.

Article data in other languages: croatian

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