Acta clinica Croatica, Vol. 40 No. 1, 2001.
Case report
Bone Remodeling by Osteoclasts: What have we learned from Gene Knockout Studies?
Martina Bašić-Koretić
Nikolina Bašić-Jukić
Abstract
Osteopetroses are disorders of bone remodeling resulting in increased bone mass. Osteopetrosis abnormalities can include changes in osteoclast lineage, bone marrow microenvironment, or both. Little is known about the mechanisms that regulate the activity of different bone cell types. Various agents act on bone in a complicated web of interactions, with either synergistic or diverse effects. Advances in molecular biology have enabled studies in knockout or transgenic animals, providing an insight into the mechanism of bone remodeling.
Keywords
Osteopetrosis, etiology; Osteoclasts, physiology; Bone remodeling, genetics; Animal
Hrčak ID:
14850
URI
Publication date:
1.3.2001.
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