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Acta clinica Croatica, Vol. 54. No. 4., 2015.

Original scientific paper

Moguća povezanost gestacijskog dijabetesa s upalom

Ayla Aktulay orcid id orcid.org/0000-0002-8094-8197 ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Yaprak Engin-Ustun ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Mehmet Sahin Ozkan ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Salim Erkaya ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Mustafa Kara ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Oktay Kaymak ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Nuri Danisman ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey

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Abstract

Cilj ovoga istraživanja bio je procijeniti je li gestacijski dijabetes melitus (GDM) udružen s upalom i to usporedbom serumskih razina humanog hitinazi-3-sličnog proteina 1 (YKL-40) te omjera neutrofila/limfocita (NLR) i omjera trombocita/limfocita (PLR). U ovo istraživanje parova bilo je uključeno 29 trudnica s GDM i 29 trudnica s normalnom tolerancijom glukoze. Dob (± 2 godine) i indeks tjelesne mase prije trudnoće bili su podjednaki u obje skupine. Mjerene su razine humanog hitinazi-3-sličnog proteina 1 (YKL-40/CHI3L1) te ispitani omjeri NLR i PLR. Nije bilo statistički značajnih razlika u dobi, gestacijskoj dobi i gravidnosti. Zabilježene su više razine YKL-40 u trudnica s GDM u usporedbi s kontrolnim trudnicama (203 (65-300) ng/mL prema 159,2 (14-290) ng/mL, p=0,007). NLR i PLR bili su značajno viši u skupini s GDM nego u kontrolnoj skupini. U zaključku, GDM je udružen s visokim razinama YKL-40, NLR i PLR koji ukazuju na upalno stanje.

Keywords

CHI3L1 protein, humani; Dijabetes, gestacijski; Leukociti, broj; Neutrofili – citologija; Limfociti – citologija; Trombociti – citologija

Hrčak ID:

155436

URI

https://hrcak.srce.hr/155436

Publication date:

1.12.2015.

Article data in other languages: english

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