Conference paper
Ena Pejković
; General County Hospital Požega, Osječka 107, 34000 Požega, Croatia
Abstract
Parkinson's disease (PD) is a chronic progressive neurodegenerative disease that damages neurons in nigrostriatal dopaminergic brain regions. It occurs in approximately 1% of the population aged over 60 years. It is believed that the etiology is multifactorial and results from interaction of genetic and environmental factors, while a large part is attributed to the action of free radicals, mitochondrial dysfunction and oxidative stress mechanism. Perhaps the most important challenge for the treatment of PD is mechanism how to delay or prevent further loss of dopaminergic and nondopaminergic neurons. This paper presents the most important results of previous studies or systematic review of preclinical data on neuroprotective agents for PD. The aim of this research is to explore neuroprotective potential of the agents in the studies with induced experimental parkinsonism. Different results and attitudes of these issues point to the need for further research with clearly defined criteria and objectives in order to obtain reliable data. Only such data can be a starting point for inclusion in clinical practice based on evidence and can greatly contribute to the development of new and effective ways of treating PD.
Keywords
Parkinson's disease; neurodegeneration; neuroprotection
Hrčak ID:
157100
URI
Publication date:
31.12.2015.
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