Professional paper

Helicobacter pylori resistance as a public health issue

Ivan Bešlić ; Medicinski fakultet Sveučilišta u Zagrebu
Stjepan Baturina ; Medicinski fakultet Sveučilišta u Zagrebu
Monika Mihalj ; Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu
Dražen Zekanović ; Opća bolnica Zadar, Služba za interne bolesti, Odjel za kardiologiju, Medicinski fakultet Sveučilišta u Osijeku
Neven Ljubičić orcid.org/0000-0002-5207-4357 ; Klinički bolnički centar "Sestre milosrdnice", Klinika za unutarnje bolesti, Medicinski fakultet Sveučilišta u Zagrebu, Stomatološki fakultet Sveučilišta u Zagrebu, Medicinski fakultet Sveučilišta u Rijeci
Jadranko Turčinov ; Opća bolnica Zadar, Služba za interne bolesti, Odjel za gastroenterologiju

Abstract

Eradication of infection Helicobacter pylori is the first step in curing diseases connected to the infection. The usual combinations of two antibiotics and one drug which suppress the gastric acid secretion (Proton-pump inhibitors – PPI) are used in treatment protocols. Combinations of drugs are divided into first-line drugs, second-line drugs and third-line drugs, taking into account that the choice of drugs in third-line is based on sensibility testing to the antibiotic of isolated strain H. pylori. Increased usage of antibiotics has resulted in greater resistance of the bacteria and finally to failure in treatment. The rise is most evident in increased resistance to clarithromycin, and recent studies show data of increased resistance also to levofloxacin. Considering that the bacteria itself has an extremely high resistance to environmental factors, the choice of antibiotics which could potentially be considered as drugs for eradication is significantly narrowed. H. pylori is a bacterium which is predominant in underdeveloped countries where there is no efficient control system regarding the increase of resistance. Due to that and the wide usage of antibiotics in general, there is a challenge which places eradication of the infection in the already infected patients on one side, and the ever growing resistance which leads to failure of infection treatment on the other side.

Keywords

helicobacter pylori; eradication; resistance; antibiotics

Hrčak ID:

159833

URI

https://hrcak.srce.hr/159833

Publication date:

7.6.2016.

Article data in other languages: croatian

Visits: 1.976 *