Professional paper

Synchronous caecal small-cell neuroendocrine carcinoma and adenocarcinoma of the rectum

Goran Zukanović ; General County Hospital of Požega, Department of Abdominal Surgery
Željko Glavić ; General County Hospital of Požega, Department of Abdominal Surgery
Goran Šantak ; General County Hospital of Požega, Department of Abdominal Surgery
Tomislav Crnković ; General County Hospital of Požega, Department of Orthopaedic Surgery
Mirela Frančina ; General County Hospital of Požega, department of Pathology
Mia Zukanović ; General County Hospital of Požega, department of Radiology

Abstract

Small-cell neuroendocrine colon carcinoma is a rare entity with a usually poor prognosis. An 80-year-old female had colon cancer surgery due to synchronous tumour of the rectum and caecum. Pathohystological analysis of the caecal tumour showed trabecular and solid clusters, relatively uniformed small to middle sized epithelial cells, deficient cytoplasm and there were a great number of mitosis with larger areas of necrosis in the connective tissue. The immunohistochemistry was positive for chromogranin A. The caecal tumour was diagnosed as a small-cell neuroendocrine carcinoma. In addition, the rectal tumour showed microscopic findings consistent with stage IIA adenocarcinoma. The immunohistochemical panel showed that the tumour was negative for neuroendocrine markers. There were no clinical findings suggestive of hormone hypersecretion. Cancer metastases were not found. Postoperative chemotherapy was applied. The patient is still alive, in good general condition and with no signs of tumour progression.

Keywords

neuroendocrine; small-cell carcinoma; caecum; immunohistochemistry

Hrčak ID:

167226

URI

https://hrcak.srce.hr/167226

Publication date:

30.9.2016.

Article data in other languages: croatian

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