Croatica Chemica Acta, Vol. 89 No. 2, 2016.
Original scientific paper
https://doi.org/10.5562/cca2863
Non-linear Optimization of Parameters in Hill Kinetics
Željko Jeričević
; Department of Computer Engineering, Technical Faculty, Vukovarska 58, HR-51000 Rijeka, Croatia
Abstract
A novel least squares optimization of parameters in Hill enzyme kinetics has been developed. The method is based on transformation into “Michaelis-Menten like” type of equation with guaranteed convergence and the initial guess equal to zero. By using this approach, a three parameters non-linear optimization problem is transformed into a one-dimensional search for Hill’s coefficient (exponential parameter n).
Numerical experiments illustrating feasibility of the method and quality of the solution are presented.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords
Hill; enzyme kinetics; non-linear; optimization; data processing; least squares
Hrčak ID:
168222
URI
Publication date:
21.6.2016.
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